Limnanthemum indicum (L. indicum.) is being used in the Ayurvedic system of medicine in India for treatment of various diseases. No systematic toxicity study for this plant was described. The present study was undertaken to assess the safety use of this plant in traditional practice. The acute oral toxicity study of aqueous extract of Limnanthemum indicum (AELI) was carried out as per the OECD guidelines 423 in mice and the sub-acute toxicity was carried out at a dose of 200 mg/kg and 400 mg/kg as per OECD 407 guidelines in male and female rats. Mice administered upto 2000 mg/kg as a single dose orally not caused any signs of toxicity or mortality in mice. In sub-acute toxicity study in rats, AELI at two different daily doses of 200 and 400 mg/kg for 28 days exhibited significant variation including the hematological and biochemical parameters. Histopathological examinations showed abnormal architecture suggesting morphological disturbances. Signs of toxicity were observed for mice in acute oral toxicity studies after administration of AELI at a dose of 200 mg/kg. Death/signs of toxicity were observed after oral administration of 400 mg/kg of AELI in sub-acute toxicity study in rats.
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